职称：讲师（校聘副研究员）

学历：博士研究生

电子邮件：weilingguo2021@163.com

研究方向：1）益生菌对肠道微生物功能的调节作用；2）乳酸菌对农产品风味的调控作用；3）微生物组学、代谢组学和转录组学解析活性成分对肠道微生物的影响

教育工作经历：

2024年5月-至今：威廉希尔中文网站 | 威廉体育williamhill | 讲师

2020年9月-2024年1月：江南大学 | 食品学院 | 食品科学与工程 | 博士

2016年9月-2019年6月：福建农林大学 | 食品科学学院 | 食品科学 | 硕士

2012年9月-2016年6月：福建农林大学 |食品科学学院| 食品质量与安全 | 本科

教学简介：

本科课程：

研究生课程：

科研简介：

现任职于福州老员工物科学与工程学院，主要研究方向涉及益生菌对肠道微生物功能的调节作用及肠道菌群与功能食品相关研究、不同乳酸菌对农产品加工/发酵过程微生物组成及代谢通路的调控作用、微生物组学、代谢组学和转录组学研究活性成分对肠道微生物的影响等方面。目前已参与发表学术论文50余篇，其中以第一（通讯）作者在Critical Reviews in Food Science and Nutrition、Food Chemistry和Journal of Agricultural and Food Chemistry等期刊发表SCI论文30余篇，文总被引近1600次，h因子25。参与国家发明专利申请4项，已获授权3项。

社会兼职：

担任Food Chemistry、Journal of Agricultural and Food Chemistry、Food Research International、International Journal of Biological Macromolecules、Free Radical Biology and Medicine、International Journal of Food Microbiology、Food & Function等10余本SCI期刊的同行评审。

科研项目：

代表性期刊论文：

1. Weiling Guo, Haoyu Zheng, Siyu He, et al., Improvement of physicochemical characteristics, bioactivity, flavor and metabolic profiles of mango juice fermented by Limosilactobacillus reuteri. International Journal of Food Microbiology, 2025, 431, 111087.

2. Weiling Guo, Wenkun Liu, Peng Liang, et al., High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice. International Journal of Biological Macromolecules, 2025, 287, 138400.

3. Weiling Guo, Bingyong Mao, Xin Tang, et al., Improvement of inflammatory bowel disease by lactic acid bacteria-derived metabolites: A review. Critical Reviews in Food Science and Nutrition, 2025, 65, 1261-1278.

4. Weiling Guo, Xin Tang, Shumao Cui, et al., Recent advance in quality preservation of non-thermal preservation technology of fresh mushroom: A review. Critical Reviews in Food Science and Nutrition, 2023, DOI:10.1080/10408398.2023.2193636.

5. Weiling Guo, Min Chen, Shumao Cui, et al., Dynamics changes in physicochemical properties, volatile metabolites, non-volatile metabolites, and physiological functions of barley juice during Bifidobacterium infantis fermentation. Food Chemistry, 2023, 141, 135201.

6. Weiling Guo, Shumao Cui, Xin Tang, et al., Intestinal microbiomics and hepatic metabolomics insights into the potential mechanisms of probiotic Bifidobacterium pseudolongum CCFM1253 prevents the acute liver injury in mice. Journal of the Science of Food and Agriculture, 2023, 103, 5958–5969.

7. Weiling Guo, Min Chen, Shumao Cui, Effects of Lacticaseibacillus casei fermentation on the bioactive compounds, volatile and non-volatile compounds, and physiological properties of barley beverage. Food Bioscience, 2023, 53, 102695.

8. Weiling Guo, Xin Tang, Qiuxiang Zhang, et al., Mitigation of dextran-sodium-sulfate-induced colitis in mice through oral administration of microbiome-derived inosine and its underlying mechanisms. International Journal of Molecular Sciences, 2023, 24(18), 13852.

9. Weiling Guo, Shumao Cui, Xin Tang, et al., Intestinal microbiomics and metabolomics insights into the hepatoprotective effects of Lactobacillus paracasei CCFM1222 against the acute liver injury in mice. Probiotics and Antimicrobial Proteins, 2023, 15(5),1063-1077.

10. Weiling Guo, Xin Tang, Qiuxiang Zhang, et al., Lacticaseibacillus paracasei CCFM1222 ameliorated the intestinal barrier and regulated gut microbiota in mice with dextran sulfate sodium-induced colitis. Probiotics and Antimicrobial Proteins, 2023. DOI: 10.1007/s12602-024-10236-0

11. Weiling Guo^#, Yingjia Cao^#, Shize You, et al., Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake. Current Research in Food Science, 2022, 5, 515-530.

12. Weiling Guo, Bingyong Mao, Shumao Cui, et al., Protective effects of a novel probiotic Bifidobacterium pseudolongum on the intestinal barrier of colitis mice via modulating PPARγ/STAT3 pathway and intestinal microbiota. Foods, 2022, 11(11), 1551.

13. Weiling Guo, Bingyong Mao, Shumao Cui, et al., Lactobacillus paracasei CCFM1223 protects against lipopolysaccharide-induced acute liver injury in mice by regulating the “gut-liver” axis. Microorganisms, 2022, 10, 1321.

14. Weiling Guo, Qunran Xiang, Bingyong Mao, et al., Protective effects of microbiome-derived inosine on lipopolysaccharide-induced acute liver damage and inflammation in mice via mediating the TLR4/NF-κB pathway. Journal of Agricultural and Food Chemistry, 2021, 69, 7619-7628. (封面文章)

15. Weiling Guo^#, Jianbin Guo^#, Binyu Liu, et al., Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet. Food & Function, 2020, 9: 3419-3431.

16. Weiling Guo^#, Min Chen^#, Wenli Pan, et al., Hypoglycemic and hypolipidemic mechanism of organic chromium derived from chelation of Grifola frondosa polysaccharide-chromium (III) and its modulation of intestinal microflora in high fat-diet and STZ-induced diabetic mice. International Journal of Biological Macromolecules, 2020, 145: 1208-1218.

17. Weiling Guo^#, Jiacong Deng^#, Yuyang Pan, et al., Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin. International Journal of Biological Macromolecules, 2020, 153: 1231-1240.

18. Weiling Guo^#, Feifei Shi^#, Lu Li, et al. Preparation of a novel Grifola frondosa polysaccharide-chromium (III) complex and its hypoglycemic and hypolipidemic activities in high fat diet and streptozotocin-induced diabetic mice. International Journal of Biological Macromolecules, 2019, 131:81-88.

19. Weiling Guo, Yuyang Pan, Lu Li, et al. Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats. Food & Function, 2018, 9, 3419-3431.

20. Xu-cong Lv, Qi Wu, …, Weiling Guo*, et al., Organic chromium derived from the chelation of Ganoderma lucidum polysaccharide and chromium (III) alleviates metabolic syndromes and intestinal microbiota dysbiosis induced by high-fat and high-fructose diet. International Journal of Biological Macromolecules, 2022, 219, 964-979. (通讯作者)

21. Xu-cong Lv, Qi Wu, …, Weiling Guo*, et al., Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating lipid metabolism and modulating intestinal microbial composition, Food & Function, 2022,13(10):5820-5837. (通讯作者)

22. Xu-cong Lv, Min Chen, …, Weiling Guo*, et al., Potential mechanisms underlying the ameliorative effect of Lactobacillus paracasei FZU103 on the lipid metabolism in hyperlipidemic mice fed a high-fat diet. Food Research International, 2021, 139, 109956. (通讯作者)

授权发明专利：

1. 一株高产肌苷缓解溃疡性结肠炎的假长双歧杆菌及其应用

2. 一株高产肌苷具有抗炎作用的副干酪乳杆菌

3. 一株高效表达腺苷脱氨酶缓解结肠炎副干酪乳杆菌

获奖情况：

1. 博士研究生国家奖学金

2. 硕士研究生国家奖学金

3. 校优秀研究生

4. 校优秀学位论文

其他

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